Endocrine Abstracts

The classic Drosophila model system has been utilized by the Heck laboratory for the characterization of novel and conserved genes essential for cell cycle and cellular physiology. The invadolysin mutation was first identified in D. melanogaster, which gave rise to abnormally-condensed chromosomes and had a lethal effect on the late larval stages. Invadolysin is a novel zinc-metalloprotease that we have shown to link cell division and cell migration ...